Protein C deficiency: Case report

Authors

  • Núbia Rojane Pinto Faculdades Metropolitanas Unidas-FMU
  • Paolo Ruggero Errante Universidade de São Paulo - USP Universidade Federal de São Paulo - UNIFESP http://orcid.org/0000-0002-6997-7587

Keywords:

Protein C deficiency, thrombosis, fulminant purpura, massive thrombosis, Ceprotin.

Abstract

Congenital protein C deficiency is a rare thrombotic disease manifested in the neonatal or early childhood period leading to the development of fulminant purpura, massive venous thrombosis with tissue necrosis, bilateral blindness from vitreous vein thrombosis, intracranial hemorrhage, and vascular failure. Patients with protein C deficiency in heterozygosis are asymptomatic until adulthood. Thrombotic episodes are caused by risk factors such as surgery, pregnancy and immobilization. We present the case of a male child hospitalized after birth with a history of purpuric lesions. Treated during the period of hospitalization with plasma, heparin, cryoprecipitate and platelets, it was diagnosed with congenital protein deficiency C, being treated with Ceprotin and enoxaparin sodium. Thus, diagnosis and early therapy are essential to avoid the serious complications resulting from the disease.

Author Biographies

Núbia Rojane Pinto, Faculdades Metropolitanas Unidas-FMU

Discente do Curso de Farmácia, Faculdades Metropolitanas Unidas-FMU, São Paulo.

Paolo Ruggero Errante, Universidade de São Paulo - USP Universidade Federal de São Paulo - UNIFESP

Departamento de Farmacologia, Escola Paulista de Medicina, Universidade Federal de São Paulo-UNIFESP, São Paulo.

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Published

2017-03-24

Issue

Vol. 5 No. 1 (2017): JAN-MAR

Section

Artigo Teórico

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