Fator de imunogenicidade e intervalo entre aplicações da toxina botulínica tipo A

Abstract

Botulinum toxin (BT) is produced by the anaerobic bacterium Clostridium
botulinum. TB can induce the formation of antibodies, reducing the duration of its effect or
even preventing its action, resulting in permanent ineffectiveness, also known as the
"vaccine effect". Serotype A is the most used in aesthetic treatments today, its clinical
response and the duration of the effect occur individually, as they depend on several factors,
such as dose concentration, interval between applications, formulations, previous exposure,
among others. The present work sought to elucidate the immunogenicity factors of botulinum
toxin type A (TBA) and to evidence the scientific findings about the intervals of its application.
Methods: 122 articles were found in the electronic database Medical Literature Analysis and
Retrieval Sistem Online, using the search term in English “botulinum toxin A facial lines”.
However, 7 articles were selected that evaluated the presence of antibodies after the
application or repetition of TBA during some cycles for the treatment of facial lines. Final
considerations: TBA proves to be effective and safe when used in recommended
concentrations and periods. However, the present work highlights the scarcity of data on its
use of TBA in smaller intervals and its possible correlation with the induction of the formation
of neutralizing antibodies.