THE IMPORTANCE OF MRI IN THE DIAGNOSIS OF HEREDITARY HEMOCHROMATOSIS

Authors

  • Ilana Félix Pinho Faculdade de Ciências Médicas da Santa Casa de São Paulo
  • Leandro Nobeschi Faculdades Metropolitanas Unidas - FMU e Faculdade de Ciências Médicas da Santa Casa de São Paulo
  • Rafael Eidi Goto Faculdade de Ciências Médicas da Santa Casa de São Paulo
  • Bergman Nelson Sanchez Munhoz Faculdades de Ciências Médicas da Santa Casa de São Paulo e Universidade Nove de Julho
  • Homero José de Farias e Melo Faculdade de Ciências Médicas da Santa Casa de São Paulo e São Camilo

Keywords:

Hereditary hemochromatosis, LIC, MRI, relaxometry.

Abstract

Hereditary hemochromatosis (HH) is a genetic disease related to iron accumulation in the body, especially in the liver. Liver biopsy is the "gold standard" protocol to diagnose the liver iron concentration (LIC), but it consist in a highly invasive technique. Other techniques, such as serum marks, are sensitive but nonspecific to LIC. Magnetic resonance imaging (MRI) is very sensitive to the presence of iron in liver. Thus, studies have sought techniques to describe LIC, highlighting the relationship signal-noise-techniques (RSR) and relaxometry. The RSR methods are currently applied in clinical practice, like Rennes"™ protocol. On the other hand, relaxometry (R2 / R2 *) generates more accurate values of LIC, however it requires a costly investment and does not have standardized protocols. MRI is widely available as a noninvasive method, moreover, it has the potential to optimize the diagnosis and monitoring of HH patients.

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Published

2016-07-06

Issue

Vol. 4 No. 2 (2016): ABR-JUN

Section

Artigo Teórico

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