The importance murine models in characterization of the immune response against leishmaniasis: a review

Authors

  • Caio Cotta Natale Departamento de Bioquí­mica e Imunologia - ICB Universidade Federal de Minas Gerais
  • Paula Melo Seixas Departamento de Bioquí­mica e Imunologia - ICB Universidade Federal de Minas Gerais
  • Daniel Manzoni de Almeida FMU FE/USP CONECTA-CIÊNCIA

Keywords:

Leishmaniasis, Leishmania amazonensis, Leishmania major, Leishmania braziliensis, Leishmania donovani/infantum.

Abstract

Leishmaniasis are diseases caused by parasites of the genus Leishmania sp. The large number of studies in the construction of knowledge about the clinical forms of leishmaniasis, especially in the field of immunology contribute for studies and understanding of immune process involved in response to infections by Leishmania.  Proposals for vaccines and drug treatments for this disease are conducted in mice models. Here, our aim was to make an enlarged and schematic review of the results obtained in recent years on the immune responses in murine models developed for leishmaniasis. We believe this systematization is important in directing studies and construction of future knowledge on leishmaniasis.

Author Biographies

Caio Cotta Natale, Departamento de Bioquí­mica e Imunologia - ICB Universidade Federal de Minas Gerais

Tem experiência nas áreas de Imunologia e Bioquí­mica, com ênfase em Imunologia.
Universidade Federal de Minas Gerais, Departamento de Bioquí­mica e Imunologia, Laboratório de Gnotobiologia e Imunologia.

Paula Melo Seixas, Departamento de Bioquí­mica e Imunologia - ICB Universidade Federal de Minas Gerais

Universidade Federal de Minas Gerais, Departamento de Bioquí­mica e Imunologia, Laboratório de Gnotobiologia e Imunologia.

Tem experiência nas áreas de Imunologia e Bioquí­mica, com ênfase em Imunologia.

Daniel Manzoni de Almeida, FMU FE/USP CONECTA-CIÊNCIA

É pesquisador e professor interessado em ciências básicas e suas articulações com o ensino. Tem como principal objeto de pesquisa a disciplina de Imunologia em três dimensões: i) o ensino de imunologia no ensino básico e superior (práticas epistêmicas nas aulas, ensino por investigação, ensino por experimentação e linguagem no ensino de ciências); ii) estudos experimentais (imunologia básica e aplicada); e iii) as suas bases histórica-filosófica (fundamentos da imunologia). Atualmente é Pesquisador Associado do Grupo de Estudos e Pesquisa em Ensino de Biologia (GEPEB) da Faculdade de Educação da Universidade de São Paulo (FEUSP) e Professor Assistente I da disciplina de CHG (Citologia, Histologia e Genética) do Centro Universitário das Faculdades Metropolitanas Unidas (FMU). íreas de atuação: ensino de biologia; ensino de imunologia; imunologia teórica, básica e aplicada.

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2016-10-04

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Vol. 4 No. 3 (2016): JUL-SET

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