A IMPORTÂNCIA DA RESSONÂNCIA MAGNÉTICA NO DIAGNÓSTICO DA HEMOCROMATOSE HEREDITÁRIA

Autores

  • Ilana Félix Pinho Faculdade de Ciências Médicas da Santa Casa de São Paulo
  • Leandro Nobeschi Faculdades Metropolitanas Unidas - FMU e Faculdade de Ciências Médicas da Santa Casa de São Paulo
  • Rafael Eidi Goto Faculdade de Ciências Médicas da Santa Casa de São Paulo
  • Bergman Nelson Sanchez Munhoz Faculdades de Ciências Médicas da Santa Casa de São Paulo e Universidade Nove de Julho
  • Homero José de Farias e Melo Faculdade de Ciências Médicas da Santa Casa de São Paulo e São Camilo

Palavras-chave:

Hemocromatose hereditária, LIC, ressonância magnética, RSR, relaxometria.

Resumo

A hemocromatose hereditária é uma doença genética relacionada ao acúmulo de ferro no organismo, principalmente no fí­gado.  A biópsia é o "padrão ouro" para o diagnóstico da concentração de ferro no fí­gado (LIC), porém é um método invasivo. Por outro lado, os exames sorológicos são sensí­veis, mas não especí­ficos.  Estudos relacionados à ressonância magnética (RM) tem sido desenvolvidos pois ela é altamente sensí­vel a presença de ferro, destacando-se as técnicas de relação-sinal- ruí­do (RSR) e relaxometria. Os métodos de RSR já são aplicáveis atualmente na prática clí­nica, principalmente o protocolo de Rennes. Já a relaxometria (R2/R2*) gera valores mais precisos do LIC, entretanto exige um investimento de alto custo e não possui protocolos padronizados. A RM é um método não invasivo e com técnicas que possuem potencial para auxiliar e aperfeiçoar o diagnóstico e monitoramento de pacientes com HH.

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Publicado

2016-07-06

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