A importância dos modelos murinos na caracterização das respostas imunológicas í s leishmanioses: uma revisão

Autores

  • Caio Cotta Natale Departamento de Bioquí­mica e Imunologia - ICB Universidade Federal de Minas Gerais
  • Paula Melo Seixas Departamento de Bioquí­mica e Imunologia - ICB Universidade Federal de Minas Gerais
  • Daniel Manzoni de Almeida FMU FE/USP CONECTA-CIÊNCIA

Palavras-chave:

Leishmaniose, Leishmania amazonensis, Leishmania major, Leishmania braziliensis, Leishmania donovani/infantum

Resumo

As leishmanioses são doenças causadas por parasitos do gênero Leishmania sp. O grande número dos estudos na construção do conhecimento sobre as formas clí­nicas das leishmanioses, principalmente na área da Imunologia, contribui para a compreensão dos processos imunológicos envolvidos na reposta í s infecções por Leishmania. Propostas de vacinas e tratamentos farmacológicos para essas doenças são, também, realizados em modelos de camundongos (murinos). Aqui, nosso objetivo foi realizar uma revisão ampliada e esquemática sobre os resultados obtidos nos últimos anos sobre as respostas imunes desenvolvidas nos modelos murinos para a leishmaniose. Acreditamos que essa sistematização é importante no direcionamento de estudos e construção de conhecimentos futuros sobre a leishmaniose.

Biografia do Autor

Caio Cotta Natale, Departamento de Bioquí­mica e Imunologia - ICB Universidade Federal de Minas Gerais

Tem experiência nas áreas de Imunologia e Bioquí­mica, com ênfase em Imunologia.
Universidade Federal de Minas Gerais, Departamento de Bioquí­mica e Imunologia, Laboratório de Gnotobiologia e Imunologia.

Paula Melo Seixas, Departamento de Bioquí­mica e Imunologia - ICB Universidade Federal de Minas Gerais

Universidade Federal de Minas Gerais, Departamento de Bioquí­mica e Imunologia, Laboratório de Gnotobiologia e Imunologia.

Tem experiência nas áreas de Imunologia e Bioquí­mica, com ênfase em Imunologia.

Daniel Manzoni de Almeida, FMU FE/USP CONECTA-CIÊNCIA

É pesquisador e professor interessado em ciências básicas e suas articulações com o ensino. Tem como principal objeto de pesquisa a disciplina de Imunologia em três dimensões: i) o ensino de imunologia no ensino básico e superior (práticas epistêmicas nas aulas, ensino por investigação, ensino por experimentação e linguagem no ensino de ciências); ii) estudos experimentais (imunologia básica e aplicada); e iii) as suas bases histórica-filosófica (fundamentos da imunologia). Atualmente é Pesquisador Associado do Grupo de Estudos e Pesquisa em Ensino de Biologia (GEPEB) da Faculdade de Educação da Universidade de São Paulo (FEUSP) e Professor Assistente I da disciplina de CHG (Citologia, Histologia e Genética) do Centro Universitário das Faculdades Metropolitanas Unidas (FMU). íreas de atuação: ensino de biologia; ensino de imunologia; imunologia teórica, básica e aplicada.

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2016-10-04

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v. 4 n. 3 (2016): JUL-SET

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