DÉFICITS COGNITIVOS NA VIDA ADULTA DECORRENTES DA QUIMIOTERAPIA APLICADA DURANTE O DESENVOLVIMENTO NEURAL NA INFÂNCIA E NA ADOLESCÊNCIA

Autores

  • Carolina Vieira Cardoso Universidade Paulista - UNIP São Paulo, SP
  • Eduardo Fernandes Bondan Universidade Paulista - UNIP São Paulo, SP

Palavras-chave:

adolescência, déficits cognitivos, quimioterapia, infância, neurotoxicidade.

Resumo

Embora tenha havido nas últimas décadas um progresso marcante nas taxas de sobrevida de crianças com câncer, é reconhecido que a quimioterapia administrada durante o perí­odo da infância e da adolescência pode exercer significativa toxicidade sobre o sistema nervoso central (SNC). Pode, por exemplo, afetar as funções neurocognitivas dos sobreviventes, inclusive com prejuí­zo no rendimento escolar/acadêmico ainda quando crianças e/ou tardiamente, em idade adulta, dessa forma influenciando de maneira expressiva a qualidade de vida futura desses indiví­duos. Modelos animais e estudos clí­nicos têm permitido a busca da compreensão dos mecanismos patogênicos que envolvem os déficits cognitivos induzidos pela quimioterapia em crianças e adolescentes, contribuindo ainda para o desenvolvimento de drogas que visem a prevenir ou minimizar os efeitos colaterais no SNC desses pacientes. Na presente revisão, busca-se apresentar estudos que descrevem a disfunção cognitiva tardia induzida pela quimioterapia aplicada no perí­odo da infância e da adolescência, discutindo os possí­veis mecanismos incriminados, suas repercussões na vida adulta e a importância dos estudos pré-clí­nicos in vivo na busca de protocolos terapêuticos que atenuem ou impeçam a ocorrência desse fenômeno.

Biografia do Autor

Carolina Vieira Cardoso, Universidade Paulista - UNIP São Paulo, SP

Programa de Pós-Graduação em Patologia Ambiental e Experimental da Universidade Paulista - UNIP

Eduardo Fernandes Bondan, Universidade Paulista - UNIP São Paulo, SP

Programa de Pós-Graduação em Patologia Ambiental e Experimental da Universidade Paulista - UNIP

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2019-06-26

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