Mutações Na Transcriptase Reversa Que Afetam o HIV-1

Autores

  • Charlotte Cesty Borda Faculdades Metropolitanas Unidas - FMU
  • Leandro S. Pinto
  • Erik Cendel Saenz Faculdades Metropolitanas Unidas - FMU

Palavras-chave:

HIV, mutações, retroví­rus, transcriptase reversa, antirretroviral

Resumo

A transcriptase reversa é a principal enzima responsável pelo processo de transcrição reversa presente no retroví­rus HIV (ví­rus da imunodeficiência humana) e vem sendo o principal alvo de pesquisas para descobrir qual droga tem melhor ação para o tratamento de pacientes que apresentam esta doença. O problema é o uso do antirretroviral durante a terapia que pode levar a transcriptase reversa a gerar mutações que alteram a sua própria estrutura, como consequência o ví­rus torna-se mais resistente à ação dos medicamentos que tentam inibir esta enzima. Existem diversas mutações que podem acometer a transcriptase, algumas têm maior ocorrência como é o caso da M184V, M184I, Y115F e Q151M e que são decorrentes de falhas por substituição, adição ou deleção de nucleotí­deos durante o processo de transcrição.

Biografia do Autor

Charlotte Cesty Borda, Faculdades Metropolitanas Unidas - FMU

 

Possuo Pós-Doc do Instituto de Ciências Biomédicas da Universidade de São Paulo, Departamento de Parasitologia, Doutorado em Biotecnologia pela Universidade de São Paulo (2007), Mestrado em Agronomia (Horticultura) pela Universidade Estadual Paulista Júlio de Mesquita Filho (2003) e graduação em Biologia pela Universidade Nacional Federico Villarreal (1999).

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Publicado

2017-06-28

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